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盐酸替布替尼(Tirabrutinib hydrochloride)是一种有效的,高选择性的,不可逆的BTK口服抑制剂。Tirabrutinib hydrochloride不可逆地共价结合B细胞中的Bruton tyrosine kinase (BTK),并在许多类型的B细胞恶性肿瘤中显示出有效的体外细胞毒性,且也在小鼠模型中显示出体内抗肿瘤活性[1]。
盐酸替布替尼(Tirabrutinib hydrochloride)是一种有效的,高选择性的,不可逆的BTK口服抑制剂。Tirabrutinib hydrochloride不可逆地共价结合B细胞中的Bruton tyrosine kinase (BTK),并在许多类型的B细胞恶性肿瘤中显示出有效的体外细胞毒性,且也在小鼠模型中显示出体内抗肿瘤活性[1]。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 197 | 现货 | |
2 mg | ¥ 283 | 现货 | |
5 mg | ¥ 479 | 现货 | |
10 mg | ¥ 828 | 现货 | |
25 mg | ¥ 1,650 | 现货 | |
50 mg | ¥ 2,480 | 现货 | |
100 mg | ¥ 3,730 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 546 | 现货 |
产品描述 | Tirabrutinib hydrochloride is a potent, highly selective, and irreversible oral BTK inhibitor. Tirabrutinib hydrochloride irreversibly covalently binds to Bruton tyrosine kinase (BTK) in B cells and exhibits potent in vitro cytotoxicity against many types of B cell malignancies, as well as in vivo antitumor activity in mouse models [1]. |
靶点活性 | BTK:2.2 nM |
体外活性 | 方法:Tirabrutinib hydrochloride(0.1-1000 nM or 0.001-100 nM; 72 h)处理DLBCL细胞系SU-DHL-6和OCI-LY10,来观察对细胞的抗肿瘤作用。 结果:Tirabrutinib hydrochloride对SU-DHL-6和OCI-LY10细胞系的IC50值是 9.127 μM, and 17.10 μM。[1] |
体内活性 | Tirabrutinib (6, 20 mg/kg; p.o.)治疗亲本TMD8小鼠, 确认替拉替尼在体内是否保持活性。 结果:0.012%的Tirabrutinib 导致小鼠体内的肿瘤缓解。[2] |
别名 | ONO-4059 (hydrochloride), GS-4059 (hydrochloride) |
分子量 | 490.94 |
分子式 | C25H23ClN6O3 |
CAS No. | 1439901-97-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 95 mg/mL (193.51 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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